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Co-cyprindiol and Duac gel

"An oral contraceptive paired with a gel you apply to your skin daily. You’ll also see co-cyprindiol as the branded pills Dianette and Clairette. Treatments help the symptoms of acne to help improve your skin’s appearance."

What is co-cyprindiol and Duac gel?

Co-cyprindiol is a contraceptive pill that combines ethinylestradiol (a type of oestrogen, the female sex hormone) with cyproterone. Cyproterone is an anti-androgen that controls how much oil your skin produces and also reduces excess hair growth.

Together, they’re an effective treatment for both the cause and appearance of mild to moderate hormonal acne in women.

As co-cyprindiol is also widely known as Dianette or Clairette, you may see this combination treatment referred to as Duac and Dianette.

How do they work?

Co-cyprindiol blocks the hormones that cause acne to stop it forming. Duac gel has two active ingredients, benzoyl peroxide (3%) and the antibiotic clindamycin phosphate (1%). They work to kill bacteria that cause acne, breaking down blackheads and whiteheads. Duac gel also reduces the inflammation and redness you often get with acne.

How to use co-cyprindiol and Duac gel

Co-cyprindiol will act as a contraceptive as well as a treatment for your acne if taken correctly. This means taking it on the first day of your period, then for 21 consecutive days at around the same time each day, followed by a 7-day break. Our clinicians will share more details about how to take co-cyprindiol.

Each evening after washing and drying your skin, apply a thin film of Duac gel to the affected area. Avoid any contact with the eyes, mouth, lips and nostrils and wash your hands after applying the gel. Be careful not to use it on skin that’s broken, irritated or sunburnt.

Treatment results

The combination targets hormonal acne from two different angles. It will be most effective if your acne is white tipped, red spots (pustules). It may take 4-12 weeks before you see a difference in your condition from this treatment, so it’s worth persevering.

Side effects of Duac gel

As with all contraceptive pills, some women may experience side effects when taking co-cyprindiol. These include changes in mood, an increase in body weight, headaches, nausea, and sore breasts.

Some people who use Duac gel may experience side effects, including a mild burning sensation, redness, dryness and peeling skin. As it contains benzoyl peroxide, this gel is likely to make your skin more sensitive to sunlight during use. So, try to protect yourself from the sun, use oil-free SPF 50 sunscreen, and avoid sunbeds or sun lamps.

For full details of side effects and correct use, please see the co-cyprindiol and Duac gel patient information leaflets. And if you’re worried about side effects, contact us in your Patient Record.

Product features

  • An effective combination treatment for women only

  • Co-cyprindiol protects against pregnancy and helps prevent acne

  • Duac gel treats the symptoms of acne

What is co-cyprindiol and Duac gel?

Co-cyprindiol is a contraceptive pill that combines ethinylestradiol (a type of oestrogen, the female sex hormone) with cyproterone. Cyproterone is an anti-androgen that controls how much oil your skin produces and also reduces excess hair growth.

Together, they’re an effective treatment for both the cause and appearance of mild to moderate hormonal acne in women.

As co-cyprindiol is also widely known as Dianette or Clairette, you may see this combination treatment referred to as Duac and Dianette.

How do they work?

Co-cyprindiol blocks the hormones that cause acne to stop it forming. Duac gel has two active ingredients, benzoyl peroxide (3%) and the antibiotic clindamycin phosphate (1%). They work to kill bacteria that cause acne, breaking down blackheads and whiteheads. Duac gel also reduces the inflammation and redness you often get with acne.

How to use co-cyprindiol and Duac gel

Co-cyprindiol will act as a contraceptive as well as a treatment for your acne if taken correctly. This means taking it on the first day of your period, then for 21 consecutive days at around the same time each day, followed by a 7-day break. Our clinicians will share more details about how to take co-cyprindiol.

Each evening after washing and drying your skin, apply a thin film of Duac gel to the affected area. Avoid any contact with the eyes, mouth, lips and nostrils and wash your hands after applying the gel. Be careful not to use it on skin that’s broken, irritated or sunburnt.

Treatment results

The combination targets hormonal acne from two different angles. It will be most effective if your acne is white tipped, red spots (pustules). It may take 4-12 weeks before you see a difference in your condition from this treatment, so it’s worth persevering.

Side effects of Duac gel

As with all contraceptive pills, some women may experience side effects when taking co-cyprindiol. These include changes in mood, an increase in body weight, headaches, nausea, and sore breasts.

Some people who use Duac gel may experience side effects, including a mild burning sensation, redness, dryness and peeling skin. As it contains benzoyl peroxide, this gel is likely to make your skin more sensitive to sunlight during use. So, try to protect yourself from the sun, use oil-free SPF 50 sunscreen, and avoid sunbeds or sun lamps.

For full details of side effects and correct use, please see the co-cyprindiol and Duac gel patient information leaflets. And if you’re worried about side effects, contact us in your Patient Record.

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Co-cyprindiol and Duac gel FAQs

  • Who can take co-cyprindiol and Duac gel?

    Co-cyprindiol and Duac gel is an effective treatment for women aged 18 to 50 years old who have mild to moderate hormonal acne. However, we only prescribe to adults over 18 years old.

  • Can I use co-cyprindiol and Duac gel while pregnant or breastfeeding?

    You shouldn't take co-cyprindiol or use Duac gel while you’re pregnant or breastfeeding. If you think you could be pregnant, we advise taking a test before starting this combination treatment.

  • Where can I buy co-cyprindiol and Duac gel?

    You’ll need a prescription to buy co-cyprindiol and Duac gel, if you’re using an online service.

    One of our clinicians can prescribe these medications after an online consultation where we make sure they’re right for you. It only takes a few minutes.

  • Co-cyprindiol and Duac gel warnings

    Co-cyprindiol

    Taking co-cyprindiol can make certain conditions worse for some people, so tell your clinician if:

    • You, or someone in your close family, has ever had problems with your heart or circulation, such as high blood pressure.
    • You, or someone in your close family, has ever had problems with blood clotting.
    • You’ve ever had migraines.
    • You currently have depression or have had it in the past. 

    There are other instances where this contraceptive pill may not suitable, and our clinicians can advise on this in a consultation.

    Duac gel

    Make sure to read the patient information leaflet included with your treatment. Our clinicians will also advise.

    • You should only use Duac gel on your skin, avoiding areas like your eyes, lips, mouth, or inside your nose.
    • Don’t use the gel on irritated or broken skin, for example on cuts, grazes or sunburn.
    • Use gel sparingly on sensitive areas of skin.
    • Most people get some skin redness and peeling during the first few weeks of using Duac gel. If your skin becomes irritated, you may need to use an oil-free moisturiser, use Duac gel less often, or pause treatment for a period of time to allow your skin to recover.
    • If Duac gel causes serious skin irritation that persists (severe redness, dryness, itching, stinging or burning) you should stop treatment and speak to your doctor or clinician.
    • Duac gel is likely to make your skin more sensitive to sunlight. So, try not to spend too long in the sun, wear protective clothing, use oil-free SPF 50 sunscreen and avoid sources of UV light like sunbeds or sun lamps. 

    Check with your clinician before using Duac gel if:

    • You’ve ever had the gut problems regional enteritis, ulcerative colitis or antibiotic-associated colitis.
    • You develop persistent or severe stomach cramps or diarrhoea, stop using Duac gel and contact your doctor immediately. These are side effects you might expect when taking antibiotics orally, not on your skin (topically).
    • You’ve recently used other medicines that contain clindamycin or erythromycin (as there’s an increased chance that Dauc gel won’t work as well as it should).
  • Do co-cyprindiol and Duac gel interact with any other medications?

    So our clinicians can prescribe an effective and safe acne treatment, you’ll need to let us know which prescription and over-the-counter medicines you’re taking regularly. This includes any medications for other skin conditions like eczema.

    Taking certain other medications at the same time as co-cyprindiol can make it less effective in protecting against pregnancy. And while using Duac gel, you should avoid: 

    • Any medications that contain the antibiotic erythromycin, oral or topical.
    • Applying any skin products that contain tretinoin, isotretinoin or tazarotene.
    • Taking medicines that contain isotretinoin, including the branded tablet Roaccutane. 
  • Alternative acne treatments

    Our clinicians can also prescribe oral antibiotics to treat your acne alongside a gel or cream, tailoring the right combination for your needs. Medications you apply to your skin (topical) may also work on their own, depending on how serious your acne is and what’s causing it. 

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